中国中老年人群高尿酸血症危险因素Meta分析
中国中老年人群高尿酸血症危险因素Meta分析 摘要 目的 系统评价中国中老年人群高尿酸血症(HUA)危险因素。 方法 计算机检索Embase、Web of Science、Pubmed、The Cochrane Library、中国知网（CNKI）、万方数据库（Wangfang data）、中国生物医学文献数据库（CBM）、维普数据库（VIP）等数据库，收集有关中国中老年人群HUA危险因素的文献，检索时限为建库至2022年3月。采用RevMan 5.3软件和Stata 14.0软件进行Meta分析。 结果 共纳入20篇文献，包括72020例HUA患者，Meta分析结果显示，高血压（OR=1.43，95%CI：1.26～1.62），年龄≥45岁（OR=1.11，95%CI：1.07～1.15），饮酒（OR=1.47，95%CI：1.31～1.65），高体质指数（BMI）（OR=1.06，95%CI：1.02～1.19），高甘油三酯（TG）（OR=1.81，95%CI：1.58～2.07），肾功能不全（OR=2.88，95%CI：1.76～4.73），高胆固醇（TC）（OR=1.21，95%CI：1.09～1.33），高血肌酐（OR=1.69，95%CI：1.53～1.85），中心性肥胖（OR=1.52，95%CI：1.30～1.79）和高尿素氮（OR=1.53，95%CI：1.23～1.90）是中国中老年人群HUA危险因素；高密度脂蛋白（HDL-C）（OR=0.59，95%CI：0.52～1.67）和高血糖（OR=0.75，95%CI：0.66～0.86）是中国中老年人群HUA保护因素。 结论 高血压、年龄≥45岁、饮酒、高BMI、高TG、肾功能不全、高TC、高血肌酐、中心性肥胖、高尿素氮是中国中老年人群HUA危险因素，高血糖和HDL-C是中国中老年人群HUA保护因素。受纳入文献质量和数量限制，本研究结论仍需更多高质量研究予以证实。关键词 高尿酸血症 HUA 危险因素 中老年 Meta分析Risk factors of hyperuricemia in middle-aged andelderly Chinese population: a Meta-analysis 【Abstract】 Objective Tosystematically evaluate the risk factors of hyperuricemia (HUA) in middle-agedand elderly Chinese. Methods Embase, Web of Science, PubMed,The Cochrane Library, CNKI and Wangfang ,Chinese Biomedical Literature Database(CBM), VIP database and other databases were used to collect literatures on riskfactors of HUA in middle-aged and elderly Chinese population, and the retrievaltime limit was established until March 2022. Meta-analysis wasperformed using RevMan 5.3 software and Stata 14.0 software. Results Atotal of 20 literatures were included, including 72020 HUA patients.Meta-analysis results showed that hypertension (OR=1.43, 95%CI:1.26-1.62), age ≥45 (OR=1.11, 95%CI: 1.07-1.15), alcoholconsumption (OR=1.47, 95%CI: 1.31-1.65), high body mass index(BMI) (OR=1.06, 95%CI: 1.02-1.19), high triglyceride (TG) (OR=1.81,95%CI: 1.58-2.07), renal insufficiency (OR=2.88, 95%CI:1.76 ~ 4.73), high cholesterol (TC) (OR=1.21, 95%CI: 1.09 ~1.33), high serum creatinine (OR=1.69, 95%CI: 1.53 ~ 1.85),central obesity (OR=1.52, 95%CI: 1.30-1.79) and high ureanitrogen (OR=1.53, 95%CI: 1.23-1.90) were risk factors for HUA inmiddle-aged and elderly Chinese population. High density lipoprotein (HDL-C) (OR=0.59,95%CI: 0.52-1.67) and hyperglycemia (OR=0.75, 95%CI:0.66-0.86) were protective factors of HUA in middle-aged and elderly Chinesepopulation. Conclusion Hypertension, age ≥45 years, alcohol consumption,high BMI, high TG, renal insufficiency, high TC, high serum creatinine, centralobesity and high urea nitrogen are the risk factors for HUA in middle-aged andelderly Chinese, while high blood glucose and HDL-C are the protective factors.Due to the limitations of the quality and quantity of the included literature,the conclusion of this study still needs to be confirmed by more high-qualitystudies.【Key words】 hyperuricemia; HUA; riskfactors; middle-aged and elderly; Meta-analysis高尿酸血症（HUA）是指体内嘌呤代谢发生异常，血尿酸生成过多或排泄减少使血清中尿酸升高的疾病。研究表明，
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